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Anabolic androgenic steroids induce an elevation in plasma testosterone concentrations and androgen receptor mRNA production in vitro (3). These effects are dependent on the presence of a specific anabolic or androgenic steroid drug (or both) because these drugs exert their effects primarily by activating the androgen receptor. However, it has been shown that the synthetic compounds that mimic anabolic steroids (3–5) also can stimulate protein synthesis and translation through an interaction with proteins of the androgen receptor that are inactivated in vivo by the antiandrogen drug tamoxifen (6). Inactivation of androgen receptors in vivo by the antiandrogen warfarin (7) seems to also contribute to the stimulatory effect of anabolic steroids. The majority of clinically significant doses of a steroid drug will cause only a transient rise in plasma testosterone concentration (1), therefore it is not possible to be certain that a given steroid, in high doses, is responsible for an increased plasma testosterone concentration.

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